The Wright Brothers' cat is called McKinley, which, like Garfield, was the name of a US President who was assassinated.
When Orson mentions 'I Love Lucy,' the underscoring quotes briefly from the Lucy theme song.
Orson Express features a character named Hermit T. Crab. This is a reference to Ernest T. Bass, a regular character on The Andy Griffith Show. Ernest T. Bass was played by Howard Morris, who is the voice of Wade Duck. Also, Safe At Home features a security guard voiced by Don Knotts, who also appeared in The Andy Griffith Show.