After a one-night relationship with a new girl, the playboy Lalo Padilla is condemned to suffer the effects of a spell cast by that vengeful woman: Lalo has become Lola and must now live as a woman who works in a publishing House.
Natalia causes Sole's resignation. Aguirre realizes how much he needs Sole working in High Five so he tells his daughter off. Sole finds herself lonely and disappointed while Lola tries to state clearly that she doesn't want anything to do with Facundo.
Lola feels some attraction towards Facundo while at his apartment. Meanwhile, Sole plans to meet a man she's known on the Internet (Mario), but he happens to be Pato, although he doesn't know Sole is his new conquest.
Gastón finds a new way to expose Lola: he forces her to undergo a medical revision alleging working issues. Secretly, he has made sure that terrible results will crop up from the tests as he has paid the doctor to do so.