TOXICA's practical effects, artwork, and most of the props are hand crafted. The film uses almost exclusively practical effects, including models, shadow morphing and puppetry.
TOXICA's wrapped shooting 3 days before the global Covid_19 pandemic and the first lock-down in the UK.
During production, director Rona Walter's father and grandfather passed away. It was only possible due to a small inheritance that principal photography could be finished, once private savings from Rona and producer Carlos Boellinger had run out.
Many things went wrong throughout pre production and before any producers came on board. To avoid later compromises to the story, director Rona Walter decided to shoot the difficult parts such as stunts and transformations, first.
The overall plot of TOXICA was inspired by the novel and 1990s cult horror, "The Relic" with Tom Sizemore by authors Douglas Preston and Lincoln Child.