This was the last episode filmed as a preventive measure for the ongoing COVID-19 pandemic
This is the second time we see Sheriff Donna Hanscum's Minnesota vanity license plate that reads "D-TRAIN" on her Ford truck. The first time was in Wayward Sisters (2018).
At 9 minutes in, the name brand of the Kentucky bourbon that Dean slides over to Sam is Field's. Field's is a possible nod to the season 5 finale location, a field, where Sam takes both Lucifer and Michael to a cage in hell. Originally Supernatural was slated to conclude with the season 5 finale.