Caroline was taken over by a Aurafacian, an alien organism that attaches to a host body. The Aurafacian was one of the aliens that Lex had transferred out of the DEO's desert facility and had never been relocated, presumably while Lex was President.
When James and Kelly are leaving, the license plate on the car is "590 WUG." This is the same license plate that is used on the getaway car used to kidnap Tanya in The Fanatical (2018).
In one scene, you can see a couple of mailboxes in the background that closely resemble the Canada post's mailboxes used all over Canada.
Caroline has similarities with DC villains Spider Lady and Spider Girl.
Sean Astin was in The Goonies (1985), which was directed by Richard Donner, who also directed Superman (1978).