During the staff meeting regarding the award of a spiral cut ham for the sales contest, a voice off camera says "I'm Jewish, you jerk." This is a cameo by the director Kevin Smith.
In the original pilot with Nikki Reed as Andi, during the scene where Sam, Sock, and Ben first encounter the fire demon, the music playing in the background is from Danny Elfman's score from Hulk (2003). The name of the track is "Hounds of Hell". Later in the show, Sock says to Sam, "You Bruce Bannered that thing, man!"
Nikki Reed who played Andi in the original pilot version was replaced by Missy Peregrym. No specific reason was given for the change.
According to an episode of the online show The SModcast, Kevin Smith said that he wanted Kyle Gass for an unspecified role, but the network turned him down. Smith was infuriated, but the character ended up being cut out of the pilot anyway.
The plaque atop the vessel box reads "Lasicate ogne speranza, voi ch'intrate". That is latin for "Abandon all hope ye who enter" a line famous from Dante's Inferno as the words over the gates to hell.