In line with Law & Order's "ripped from the headlines" tradition, this episode took inspiration from the case of Dr. Cecil Jacobson, an American fertility doctor who used his own sperm to impregnate his patients without their knowledge or permission. Authorities confirmed via DNA testing that 15 children were fathered by Dr. Jacobson, though it's possible a total of 75 babies were conceived using his sperm.
Wiskott-Aldrich syndrome is a rare genetic disease that usually only affects men. (Only about one in a million boys born with this genetic mutation will develop symptoms.) The syndrome is characterized by eczema; thrombocytopenia (low platelet count); immune deficiency; and bloody diarrhea (which is due to blood not clotting because of the low platelet levels). The first signs of the syndrome are usually petechiae (red or purple spots on the skin, caused by a minor bleed from broken capillary vessels) and bruising, resulting from a low platelet count. Spontaneous nose bleeds and bloody diarrhea are also common, and eczema typically develops within the first month of life.
First appearance of Detective Nola Falacci (Alicia Witt) who teams up with Mike Logan (Chris Noth). In reality, Julianne Nicholson was on maternity leave.
Danny Burstein (Leo Bernardi) previously played the role of Luke Vinton in episode 3.15, Shrink-Wrapped (2004).
Chris Noth (Mike Logan) & Kate Hodge (Paula Rush) also worked together on episode 5.10, The Decision Tree (2013), of The Good Wife (2009), as Peter Florrick & Lila Ashbaugh respectively.