This series is loosely based on JoJo Siwa's YouTube vlogs. Her catchphrase "Yo yo!" is heard like in the beginning of her videos. Some of the background music are instrumental versions of her popular songs.
The animation design is based off the JoJo Siwa art style that has been seen in marketing brands. This show had also spawned a book series that continued after this show had ended.
JoJo Siwa's animated friends in this series are not her actual friends in real life as they are just written for the show itself and voiced by a small number of teen actors.
JoJo Siwa's first time voice acting in her career. She eventually did performances in The Angry Birds Movie 2 (2019).
The first animated show to be produced by Nickelodeon Entertainment Lab animating the entire series in motion capture.