The "To be continued . . . " ending parodies The Best of Both Worlds (1990), complete with identical titling and similar dramatic music. Patrick Stewart, who has a cameo in the follow-up episode Lois Kills Stewie (2007), played Captain Picard in it.
This episode and the following episode, with the title names reversed (Stewie Kills Lois (ep 6.4) and Lois Kills Stewie (ep 6.5)), were originally broadcast back-to-back on November 4, 2007 as a 2-parter.
In this episode, Quagmire compares Peter to killer Bernie Goetz. In actuality Bernie Goetz shot 4 teens in 1984 on a subway car, paralyzing one of them, but has never killed anyone.
Carter Pewterschmidt committed perjury for lying in court about Peter killing Lois and calling him after he killed Lois and Carter also committed murder when he murdered an Asian hooker on camera. He made all of it up because he hates Peter but yet, he doesn't get punished.
Although being aired in an evening time-slot this episode underwent heavy editing on German Television.