Melendez co-wrote the script with Schiff Shartenberg. However, Shartenberg asked for his name to be removed from the credits after a falling out with Melendez.
John Melendez originally asked Artie Lange to play Jeffrey Ross' character ("Ernie"), but Lange was unavailable due to being in rehab to overcome his drug problems.
Melendez admitted on his podcast, that whilst filming the bathroom scene, he did actually defecate during a take, thinking people on set would find it hilarious. However, the crew were not amused and Melendez was forced to apologise before filming could continue.
The title is taken from a Victorian concept that primitive cultures have words for the numbers one and two, but beyond that refer to any greater quantity as "many."
The actor Patrick Buckley was John's friend from when both appeared in the play Tony and Tina's Wedding; both appeared together on The Howard Stern Show promoting the play (where John worked of course).