- Janine Melnitz: [Slimer's eaten everything in the house] I tried to stop him. You guys don't need a receptionist, you need a babysitter, a whole platoon of them!
- Winston Zeddemore: Yeah, just because you had a bad day, that's no reason to take it out on Slimer.
- Dr. Peter Venkman: I don't care! I don't like him! I've never liked him!
- Dr. Egon Spengler: Maybe that's part of the problem. Maybe he eats because he wants to feel accepted. Remember, he's a ghost living with a bunch of guys whose job it is to bust ghosts. How would you feel?
- Dr. Peter Venkman: Hey Ray, I'm going next door to complain. They're playing their stereo too loud again. Wanna come?
- Dr. Peter Venkman: Hey, that was great, really great. Can we do it again?
- Doomsday Door: Do not open until Doomsday.
- Dr. Peter Venkman: It was just an idea.
- Dr. Peter Venkman: [quietly, to Slimer] You breath a word of this to anybody and I'll deny it.
- [feeds Slimer a pizza]
- Dr. Peter Venkman: Goodnight, Slimer.
- Egon Spengler: [referring to the writing on a stone tablet] It's Sumerian.
- Winston Zeddemore (I): Can you read Sumerian?
- Egon Spengler: In my sleep. Underwater and with the lights off. Of course I can read Sumerian.
- [the Ghostbusters discover that they must be trapped in the Doomsday Door without a chance of escape in order to close it and save the world]
- Dr. Peter Venkman: [yelling over wind] Egon, you kidder! I'll bet you knew this all along and just didn't tell us! Am I right?
- Egon Spengler: [yelling] It's our only chance! But I figured if I told you the whole story, you wouldn't want to do it!
- Dr. Peter Venkman: That's a terrible thing to say, Egon! You're right, of course, but it's still a terible thing to say! Well, if we're gonna go out, lets do it style, I got an image to protect.
- Winston Zeddemore: [people are cheering for the Ghostbusters] I think they like us.
- Dr. Egon Spengler: I don't know, it could be a trap.
- Dr. Raymond Stantz: Unless we do something to stop it, the whole world will soon smell just like your socks. Eternal darkness, and the Earth will be governed by ghosts.
- Dr. Peter Venkman: No more days at the beach?
- Winston Zeddemore: No more beach.