- Harvard symbologist Robert Langdon works with a nuclear physicist to solve a murder and prevent a terrorist act against the Vatican during one of the significant events within the church.
- Following the murder of a physicist, Father Silvano Bentivoglio, a symbolist, Robert Langdon, and a scientist, Vittoria Vetra, are on an adventure involving a secret brotherhood, the Illuminati. Clues lead them all around the Vatican, including the four altars of science, Earth, Air, Fire and Water. An assassin, working for the Illuminati, has captured four cardinals, and murders each, painfully. Robert and Vittoria also are searching for a new very destructive weapon that could kill millions.—XXDustfingerXX
- After the untimely death of Pope Pius XVI, a momentous crisis hits the Vatican as a long-forgotten enemy of the Catholic Church emerges, threatening the lives of four abducted cardinals. Having caught the Church's attention after the events of The Da Vinci Code (2006), Harvard symbologist Professor Robert Langdon embarks on a time-sensitive mission to unravel the mystery of a murdered Italian physicist and prevent a terrorist act against Vatican City. Under those grave circumstances, Langdon teams up with CERN scientist Dr Vittoria Vetra to follow a faint trail of clues scattered all over Rome, triggering a high-stakes cat-and-mouse game. But in this frenzied quest for answers and the world's most potent and volatile energy source, the elusive adversary is always one step ahead of them. Can Langdon piece the evidence together and outsmart the Illuminati, the most dangerous secret brotherhood in history?—Nick Riganas
- Despite his notorious relationship with the Roman Catholic church, Harvard symbologist Robert Langdon is once again called upon to decipher the clues to a catastrophic conspiracy. The Pope has died, and before a conclave can begin to determine his successor, the four preferitti (primary hopefuls for the papacy) are kidnapped. An ominous threat of their hourly demise, along with the complete annihilation of Vatican City, is issued as an elaborate revenge scheme by a persecuted group known as the Illuminati. With their meager time limit steadily counting down, Langdon, accompanied by beautiful physicist Vittoria Vetra, must travel throughout Rome to unravel the carefully hidden signs that will lead them to a terrifying adversary, a harrowing discovery, and the shocking truth.—The Massie Twins
- The Pope has died and the conclave has been called. Four candidates have been chosen. However, before the voting, the four candidates are killed one by one. The killer leaves clues that seem to say that he or she is a member of the Illuminati. Strangely though, the Illuminati was long thought to be eradicated. Who is the mastermind? Who revived the Illuminati? What do they want?—Ryanking
- Under the watchful eyes of Father Silvano Bentivoglio (Carmen Argenziano) and Dr. Vittoria Vetra (Ayelet Zurer), the European Organization for Nuclear Research (CERN) initiates the Large Hadron Collider and creates three vials of antimatter particles larger than any that have ever been produced before. Almost immediately, Father Silvano is killed and one of the vials of antimatter goes missing. At the same time, the Roman Catholic Church is mourning the sudden death of Pope Pius XVI in Rome and prepares for the papal conclave to elect the next Pope. The Camerlengo Patrick McKenna (Ewan McGregor) assumes temporary control of the Vatican. The Illuminati kidnap four of the 'Preferiti' (the favorite cardinals to be elected pope) before the conclave enters seclusion and threaten to kill one candidate every hour and destroy all of Vatican City at midnight, using the missing vial of antimatter as a bomb. The Vatican summons Symbologist Robert Langdon (Tom Hanks) from Harvard University and Vittoria from CERN to help them save the four Preferiti and locate the vial.
Langdon listens to the Illuminati's message and deduces that the four cardinals will die at the four altars of the "Path of Illumination," marked by statues of angels in locations relevant to the four classical elements. Over the objections of Commander Maximilian Richter (Stellan Skarsgård), head of the Swiss Guard, but with McKenna's consent, Langdon is granted access to the Vatican Secret Archives. He examines Galileo Galilei's banned book with Vetra. Following the clues and accompanied by Inspector General Ernesto Olivetti (Pierfrancesco Favino), and Claudio Vincenzi (David Pasquesi) of the Vatican Gendarmerie Corps, they arrive at the Chigi Chapel in the Church of Santa Maria Del Popolo. There they find Cardinal Ebner (Curt Lowens) dead, suffocated with soil and branded with an Ambigrammatic word "Earth". They verify the second location is Saint Peter's Square but are unable to save Cardinal Lamasse (Franklin Amobi); his lungs punctured, and his body branded with "Air".
While Vetra studies Silvano's diaries, Langdon, Olivetti and Vincenzi locate the third church, Santa Maria Della Vittoria, but are unable to save Cardinal Guidera (Bob Yerkes) from being burned to death. His body is branded with an Ambigrammatic word, "Fire". The assassin (Nikolaj Lie Kaas) appears and brutally kills Olivetti and Vincenzi, while Langdon barely manages to escape with his life.
Langdon and two Carabinieri officers (Victor Alfieri and Todd Schneider) race to the Water altar, the Fountain of the Four Rivers, where the assassin murders the officers and drops a bound and weighted Cardinal Baggia (Marco Fiorini) into the fountain. Langdon, assisted by bystanders, saves the cardinal, who tells him the Illuminati's lair is Castel Sant'Angelo. There Langdon and Vetra discover a hidden passageway leading to the Vatican, being used as a hideout for the assassin. Discovering a case with marks for five branding irons, they realize the fifth brand is for the Camerlengo but are confronted by the assassin before they can alert McKenna. The assassin spares their lives, then cryptically warns them that his contractors were "men of God". He escapes but is then killed when his car explodes.
Inside the Vatican, Langdon and Vetra find Commander Richter hovering over McKenna with a gun, the Vatican symbol branded into McKenna's chest. Richter and Archbishop Simeon (Cosimo Fusco) are shot by the Guards, and Langdon takes a key that slips from Richter's hand. The stolen antimatter vial is found in St. Peter's Tomb below the church, but the battery life is too low to risk re-connecting it to a battery. McKenna, a former military pilot, seizes the vial and uses an awaiting helicopter to fly above the Vatican.
At a high altitude, he parachutes out as the antimatter bomb explodes overhead. McKenna is hailed a hero and savior, and the cardinals move to elect him pope. Langdon and Vetra use Richter's key to watch a security video showing McKenna speaking to Richter before the attack. The video reveals that it is McKenna, not the Illuminati, who masterminded the scheme; intending to use the incident to be named Pope and to rally the church's most conservative followers to his side. The recording is shown to the Papal conclave, and when it dawns on McKenna that he has been exposed he flees to a remote recess in the building where he is able to commit suicide by setting himself on fire.
The Vatican officially announces that McKenna died due to internal injuries suffered during his parachute landing, and Cardinal Baggia is named Pope Luke I, with Cardinal Strauss as the new Camerlengo. Strauss thanks Langdon for his assistance and gives Langdon Galileo's "Diagramma Veritatis" for his research, requesting only that Langdon's will contain a bequest that it be returned to the Vatican, and that any future references he makes to the Catholic Church in his future publications be done "gently".
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