Guest star Jack Black was in a long term relationship with Laura Kightlinger (nurse Sheila) at the time. They dated from 1997 to 2005. Besides occasionally playing nurse Sheila, Kightlinger wrote 6 episodes of Will & Grace between 2000-2005.
Debra Messing only had a small appearance in this episode, in a scene at the very beginning of the episode, where she was at KFC on the phone with Will.