- Team Knight Rider must stop Dr. Toma from infecting the world's biggest rivers with the deadly compound he has been making in his secret lab on the island of San Cartega.
- Several bikini-clad women (Laurie Carrasco, Elan Carter, Tracy Stockwell, and Kim Gagliano) stop a passing transport truck, claiming they have car problems. They knock out the two guards (Ned: Jim Meskimen, Dan: Marc Silver) and steal a shipment of Tanus Root virus (biohazard level four) which is the trucks cargo.
TKR is responsible for locating Doctor Adam Toma (Kevin West) who is believed to be behind the theft. In order to find him, Jenny assigns the team members to various tasks that end up pairing her to work with Kyle. Maybe Jenny has a crush on Kyle. Capt. Wyatt and Kyle have a history with San Cartega Island but it is classified. While flying to San Cartega, they enter restricted air space and are instructed to turn around. Wyatt figures it is a left-over automatic beacon from Kyles previous mission and continues. Dr. Toma has his electronic beam very bumpily force SkyOne to land. Duke, Trek, and Beast are dropped out of SkyOne onto the Island. The rest of the team tries to figure out what happened to the plane. Short-range communication is out so the two groups cannot contact each other. Duke and Trek run into three women who claim that the island is a spa for women only. The women take them to the main area which includes an off-limits building. Trek and Missy (Elizabeth Hobgood?) go back to work on Beast. Duke enters the building and gets caught in the Security Office. Erica volunteers Jenny to go to the Island (because of Jennys training and Erica is too wussy to go). Jenny emerges from the sea and Missy just happens to have an extra bikini in her bag.
Dr. Toma is planning on infecting the world's biggest rivers with the deadly compound he has been making in his secret lab on the island of San Cartega. Duke with Jenny and Trek with Missy corner the women pilots who have canisters of the virus and are planning to deploy them. They get most of the pilots. One of the pilots escapes and Beast misses while trying to shoot her down. The rest of the team is still working on SkyOne. SkyOne finally reaches Jenny and she warns Kyle about the escaped pilot and her mission. SkyOne is barely functional and they cannot contact the local authorities so SkyOne has to catch her. Jenny tells the women why they are really on the island (Dr. Toma plans to eradicate the entire world population except for him and the women. After he destroys the world, he plans on repopulating the earth with the women.) The women dont take the news lightly and overtake the security guards and Toma. Trek figures out how to worm the deployment location out of the germaphobic Toma. Security Officer: Lucy Goncalves, Co-Pilot: Chris Faulk, Gil (mechanic): Vince Waldron, Bather 2: Allison Moreno
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