Meg claims that she met "Something Michael Murray" in an L.A. bar. This is a reference to Chad Michael Murray, who Jared Padalecki's characters in Gilmore Girls (2000) and House of Wax (2005) feuded with Murray's characters. Chad and Danneel Ackles, Jensen Ackels's (Dean) wife have stared together in One Tree Hill. Danneel also plays a character in later seasons of Supernatural. The boys' dad, Jeffery Dean Morgan is married to Hillary Burton, who stars also on one tree hill.
In this episode the victims name is Meredith. At the beginning of the episode she gets a phone call from a Derek. In Grey's Anatomy (2005), Meredith and Derek are the main love interest for the show. Also, the actor who plays John Winchester (Jeffrey Dean Morgan) plays Denny Duquette on Greys, along with Missouri the psychic (Loretta Devine) who plays Adele Webber on Greys.