When Bob Ballard is giving his fact end-cap over the final credits, the red submersible behind him bears the writing 'NCC 1701 B.' Storyboard artist for SeaQuest, John Eaves, went on to work heavily as a production designer for numerous Star Trek projects, including designing the first Starship Enterprise not to be captained by James T. Kirk in the film Star Trek Generations (1994). This vessel's registration was NCC 1701-B.
The title references Patrick Henry's "Give me liberty, or give me death" speech which he gave at the Second Virginia Convention on March 23, 1775.