"Hollywood Madam" Heidi Fleiss, operator of an upscale prostitution ring based in Los Angeles, was arrested in June 1993, a few months before this episode aired.
The title is from the expression "I don't know you from Adam."
Candice Bergen starred in Mayflower Madam (1987). It was based on the true story of Sydney Biddle Barrows, a socialite from a prominent family who ran an escort service for powerful, wealthy clients from 1979 to 1984.