This story is loosely based on the murder of wealthy investment banker Ted Ammon, including the style of the murder, the ailing soon-to-be ex-wife, the adopted Soviet-era Eastern European twins, a jealous blue-collar lover, and other assorted minor characters, suspects, and events.
It is mentioned that the children were in the Romanian Constantin Virnav's orphanage before to be adopted in USA. Constantin Virnav is a street in the city on Chinisau, Moldova. Virnav (1806-1877) was a doctor who between 1849-1855 assisted to create Moldovian's health system, as well as an important politician in Romania Parlament.
Reiley McClendon (Jason Connors) also played twins Lindsay/Logan Stanton in the Law & Order: Special Victims Unit episode "Identity."
Prelone is the brand name for a oral solution of the corticosteroid prednisolone, which is almost identical to the drug in the tablets Mrs. Connors was taking, which were prednisone. It would be unusual for a doctor to prescribe two different corticosteroids as the same time as the risk of serious side effects, like hyperglycemia, would be very high. Prednisolone is usually prescribed to people that have certain metabolic issues that prevent their liver from metabolizing prednisone; unlike most drugs prednisolone does not need to be metabolized first, normally the liver metabolizes prednisone into prednisolone, which is why prednisolone is normally only prescribed to people with liver issues. So it would be very unusual for someone being prescribed prednisolone to also be prescribed prednisone for that reason as well.