First time a parent of one of Dr. House's team (Chase) shows up.
This is the first time the oft-mentioned (and always wrong) diagnosis of sarcoidosis is brought up as a possible cause for the patient's condition.
Actor Nestor Carbonell would later direct an episode of The Good Doctor, another medical drama co-created by "House" creator David Shore.
Nestor Carbonell and Tracy Middendorf would both later appear on Lost.