Charlayne Woodard, the actress who portrays the youngest of the Smith sisters, is actually the oldest in real life.
When the delivery man arrives with green patio furniture for the wedding, Hilary tells him it's not a Ninja Turtles wedding. James Avery who plays Phil, did the voice of Shredder in the original Teenage Mutant Ninja Turtles (1987) animated series.
The first episode where the end credits is coupled with live action, whether scripted or outtakes.