The scene where Freakazoid yells at Jeepers was improvised by Paul Rugg. Originally, Freakazoid was only supposed to say, "No!", but Rugg went on a long rant instead.
In 'Dance Of Doom,' Freakazoid seems more interested in Val than Steff, but after this episode Steff is established as his girlfriend and Val is never seen again.
The character dynamic between Steff and Valerie was a parody of the Archie Comics characters, Betty and Veronica.
The little man in a brown suit that appears in every episode is Emmitt Nervend, his name also appears in the end credits now and again.
Freakazoid's shtick with Hand Man is an homage to the famous ventriloquist Señor Wences, whose most famous character was drawn on his hand.