The first appearance of "Opie".
First appearance of Peter's boss Angela, voiced by Carrie Fisher.
The scene in which the Griffins are running toward the river to escape by the plane, when the wild tribe is chasing them, is the reference to the opening scene of the Raiders of the Lost Ark (1981).
The ongoing joke is that nobody can understand what Opie is saying because of his garbles.
The episode makes fun of the 2005 film Bewitched (2005) and, more specifically, its star Will Ferrell. Ferrell himself has voiced characters on Family Guy (1999)