Ethyl mentions her friends Dorothy, Rose, and Blanche have begged her to move in. These are the names of three of the Golden Girls (1985)
Ethyl graduated from Primordial High in 60,000,062 BC.
This episode takes place in 60,000,002 BC.
The title is a parody of Driving Miss Daisy (1989), where Morgan Freeman plays a hired driver to an incorrigible elderly woman (Jessica Tandy) .
The scene where Earl and Ethyl are in the car and feel the footsteps coming and making concentric circles in the drink on the car dashboard because of an approaching monster is a parody of the tyrannosaurus rex main road attack from Jurassic Park (1993)