Joe Penny, who plays Det. Reggie Ackroyd, had previously starred on Jake and the Fatman, which Diagnosis Murder is a spin-off from. The character of Dr. Mark Sloan made his first appearance in the episode, "It Never Entered My Mind."
Martin Kove(Cagney &Lacey), Joe Penny(Jake & the Fatman) and Reginald Veljohnson(Family Matters) all played cops previously and star in this episode about police officers