When the doctor vaccinates the little girl he gives her only a single needle poke.
In fact small pox vaccine is administered by series 15 to 30 very shallow needle
pokes. In the 1950s and 60s a multi-pronged administration device was developed
that made giving the vaccine easier.
Flora refers to Joanie as a "dyke," a term that wasn't in use until the 1930s.
At about 25:45, when Doc Cochran is leaving Alma's room, you hear the door slam before it is fully closed.