Busy Phillips (Audrey) and Seth Rogan (Bob) were co-stars on the tv show Freaks & Geeks
Michelle Williams (Jen) and Seth Rogen (Bob) would later both star in the movie Take This Waltz (2011).
Pacey and Jack are completely absent in this episode.
During the road trip, when Audrey wakes up she asks Joey where they are. Joey responds "somewhere in North Carolina." Unless the goal is a leisurely road trip, there's no reason or logic to drive from Boston to Los Angeles via North Carolina. It would add an additional 5 hours and 300 miles to the trip.