Twenty-seven years after this episode was aired, Kimmy's voice actress, Elisabeth Moss, would star in the film The Invisible Man (2020). Kimmy's mother Helen shares a similar arc to Moss' character Cecilia, in that she is trying to get away from her abusive, invisibility suit-clad husband.
Noted Bruce Timm, "An invisible man works really well in animation, even better than it does in live action. We have total control over the scene. We can do things that would take zillions of dollars to do in live action."
In an earlier draft of the script, Kimmy was going to be dragged along during the final chase scene and the invisibility suit was in danger of exploding before Batman could save her, the storyline was scrapped because of censorship rules against showing endangerment of children.
Originally the episode's production number was assigned to an episode entitled 'The Count and the Countess.' Bruce Timm sent it to a Japanese studio for complete preproduction work as an experiment. He thought it would free up the in-house staff's time for better shows. The overseas studio took months to produce even character designs and a partial storyboard, and those were drawn in a style too off-model to be useable. Production on the first season was nearing an end and with a troubled script and unacceptable preproduction work, the episode was killed. When this episode was completed (the 57th or 58th show finished), it was assigned the lower production number left empty.
The material being cited as having an effect on a person's sanity is likely a reference to The Invisible Man, who himself went insane due to a chemical he used in his formula