On Tuesday, 2nd August 2022, the British Broadcasting Corporation announced that after 17 years on air the comedy panel show is to end. A final run of 8-episodes will be broadcast in Autumn 2022. The BBC commented that they had taken the difficult decision to end the programme to make way for new shows. Dara O'Briain joked "That's it folks, the UK has finally run out of news. The storylines were getting crazier and crazier, global pandemics, divorce from Europe, novelty short-term Prime Ministers. It couldn't go on...We just couldn't be more silly than the news was already."
On 2 October 2009, Frankie Boyle announced he was leaving the show to concentrate on other projects. It was announced to the public via Facebook on the "Mock the Week" fan page, and later confirmed by the BBC. Fans of the star soon rallied around to get him to stay, and a popular Facebook group was made straight away, showing how strongly the fans felt about Boyle and his place on the show. However, Boyle has since criticised both the show's production team, and the BBC Trust. He claims that the show did not cover enough major news stories and was too restrictive on his risque comedy act, as the producers and the BBC Trust were afraid of "frightening the horses".
The sixth show of series one was cancelled as it was being recorded in central London on 7/7. A compilation was put out instead.
According to Dara O Briain, Milton Jones' were the hardest to edit, because both audiences and fellow comics were laughing so hard.