The first season was produced in the United States by Warner Bros Animation and was animated through traditional animation with the voice cast coming from Canada (with the exception of James Arnold Taylor voicing the main character). Sometime after production of Season 1 ended, the WB Network, which was the channel the show was running at the time merged with UPN which resulted budget cuts forcing most of the crew from the show to be laid off and production was resumed in Canada by Cookie Jar Entertainment (later DHX Media) and animated in Flash starting with Season 2 and so on. Only the show's creator Scott Fellows and the voice cast from the first season continued to work on the show.
The characters Susan and Mary Test are named after creator Scott Fellows's own sisters.
The show has been referred to as an anime despite it being a Canadian cartoon.
Dukey the dog was originally named Poochie.
The White and Black government agents are a parody of Agent J and Agent K of The Men in Black.