The first WrestleMania to feature the Money in the Bank Ladder Match the second overall ladder match in the event's history however the only one on one ladder match was at WrestleMania X.
This would be Eddie Guerrero's final WrestleMania appearance before his untimely passing on November 13, 2005. He had previously appeared at WrestleMania 2000, WrestleMania X-Seven, WrestleMania XIX, and WrestleMania XX before he would be inducted into the WWE Hall of Fame Class of 2006.
This is the first Piper's Pit segment at a WrestleMania since WrestleMania V.
The television advertisements for WrestleMania 21 were parodies of famous scenes from famous films because this WrestleMania took place in Los Angeles. The scenes were performed by the WWE Superstars. The films were:
-A Few Good Men (1992) (played by John Cena, John "Bradshaw" Layfield (John Layfield) and Jonathan Coachman).
-Taxi Driver (1976) (played by Jon Heidenreich, Batista (Dave Bautista), Shawn Michaels, Rey Mysterio (Rey Mysterio), Shelton Benjamin, The Basham Brothers (Dan Hollie and Doug Basham), Big Show (Paul Wight), Candice (Candice Michelle), Carlito (Carlos Colón Jr.), Tajiri (Yoshihiro Tajiri), Orlando Jordan, Victoria (Tara), Snitsky (Gene Snisky), Paul London, Tazz (Peter Senerchia), Hardcore Holly (Bob Howard), Molly Holly (Nora Greenwald) and Michael Coulthard).
-Basic Instinct (1992) (played by Stacy Keibler, Chris Benoit, Christian (Jay Reso), Chris Jericho, The Fabulous Moolah (Lillian Ellison) and Mae Young).
-Forrest Gump (1994) (played by Eugene (Nick Dinsmore) and William Regal (Darren Matthews)).
-Dirty Harry (1971) (played by Undertaker (Mark Calaway)).
-When Harry Met Sally... (1989) (played by Christy Hemme, Kurt Angle and Linda McMahon).
-Pulp Fiction (1994) (played by Eddie Guerrero and Booker T (Booker Huffman)).
-Braveheart (1995) (played by Triple H (Paul Levesque) and Ric Flair).
-Gladiator (2000) (performed by "Stone Cold" Steve Austin).
-Taxi Driver (1976) (played by Jon Heidenreich, Batista (Dave Bautista), Shawn Michaels, Rey Mysterio (Rey Mysterio), Shelton Benjamin, The Basham Brothers (Dan Hollie and Doug Basham), Big Show (Paul Wight), Candice (Candice Michelle), Carlito (Carlos Colón Jr.), Tajiri (Yoshihiro Tajiri), Orlando Jordan, Victoria (Tara), Snitsky (Gene Snisky), Paul London, Tazz (Peter Senerchia), Hardcore Holly (Bob Howard), Molly Holly (Nora Greenwald) and Michael Coulthard).
-Basic Instinct (1992) (played by Stacy Keibler, Chris Benoit, Christian (Jay Reso), Chris Jericho, The Fabulous Moolah (Lillian Ellison) and Mae Young).
-Forrest Gump (1994) (played by Eugene (Nick Dinsmore) and William Regal (Darren Matthews)).
-Dirty Harry (1971) (played by Undertaker (Mark Calaway)).
-When Harry Met Sally... (1989) (played by Christy Hemme, Kurt Angle and Linda McMahon).
-Pulp Fiction (1994) (played by Eddie Guerrero and Booker T (Booker Huffman)).
-Braveheart (1995) (played by Triple H (Paul Levesque) and Ric Flair).
-Gladiator (2000) (performed by "Stone Cold" Steve Austin).
The Undertaker's match with Randy Orton was the first time he wrestled specifically in defense of his undefeated WrestleMania streak.