Maruska is a young girl who has a rare genetic disorder that causes her to have a very low immune system. She becomes friends with Honza, who visits her and brings her gifts.
Zuzka is a teenage girl who suffers from anorexia nervosa. She is obsessed with her weight and appearance. She meets Michal, who is recovering from his bed wetting problem. He tries to help her overcome her problem and see her true beauty.
Dr. Snajberková is the hospital's director and the main protagonist of the series. She has to deal with various challenges and pressures. She also has to balance her work and family life, as she is a single mother of two daughters.