This was Gloria Stuart's final acting role before her death on September 26, 2010 at the age of 100.
Every member of the cast and crew received the same wage of US$100 a day.
At a public screening director Wim Wenders revealed that, just after his film Don't Come Knocking (2005) was delayed for a year, he found himself with plenty of time and the urge to shoot. He developed a treatment in just 3 days, worked on the screenplay for 3 weeks with the cast and crew and directly after that shot the entire movie in only 16 days.
When Lana and Paul are talking on the roof, a sign can be seen in the distance reading "The New Million Dollar Hotel". This can be seen as a reference to Wim Wenders' film The Million Dollar Hotel (2000), but the hotel is actually right next to Skid Row in Los Angeles, where most of this film was shot.