- A small town, desperate to recover from hard economic times, is under threat when voracious Snakehead fish mutate and survive previous lake chemical poisonings.
- Two years after the desperate attempt to eradicate the snake-head menace in Maryland's once-serene Cultus Lake, the fish population continues to decline. However, as if that weren't enough, someone thought that it would be a great idea to fill the lake with potent growth hormones to increase the lake fisheries, resulting in the creation of a mutated strain of more powerful and more ferocious aquatic predators. Now, Sheriff Patrick James and the marine biologist, Lori Dale, have to right a wrong, before the now-uncontrollable monsters decimate the entire community. Do they have what it takes to stop the snake-head terror?—Nick Riganas
- A small town, desperate to recover from hard economic times, is under threat when voracious Snakehead fish mutate and survive previous lake chemical poisonings. The fish transform from pests to predators when human growth hormones are dumped into the local lake in the hopes of reviving the local fishing industry. Thriving on the hormones, the Snakehead fish grow to monstrous proportions, devouring everything within reach. Capable of moving and eating on land, they are forced to leave the now barren lake in a desperate search for food - animal, vegetable or human.—Anonymous
- Snakehead fish invade Cultus Lake in the small town of Cultus, Maryland, although the town's police department poisons the lake, seemingly killing all of the fish. Two years later, bodies begin showing up in the lake, with town sheriff Patrick James temporarily closing off the lake. After Patrick's daughter Amber's boyfriend James, and James' friend are eaten by unseen creatures, the bodies are inspected, and local doctor Jenkins gives Patrick a tooth he found in one of the bodies. Patrick attempts to convince the town's mayor to shut down the lake, although to no avail, as the town is suffering from economic troubles.
Marine biologist Lori Dale soon arrives in town to help Patrick determine the cause of the recent deaths. Lori identifies the creatures as unusually large snake heads. She theorizes that something in the lake is causing the snake heads to grow in size. After more deaths occur, Lori discovers that the snake heads have been drugged with human growth hormones to make them larger. A fisherman that captures one of the snake heads, convincing the mayor even further that the lake shouldn't be closed, believing that the captured snake head was the only one. While Patrick, and Lori head out on the lake to find the source of the hormones, Amber convinces her friends Jagger, Luke, and Craig to help her kill the snake heads in order to avenge James.
Patrick, and Lori find an overturned boat on the lake, and encounter the snake heads. They attempt to head back to shore, only to find Jenkins' brother Colin pouring something into the lake. Colin flees as they attempt to catch him, and Lori discovers the the liquid Colin was pouring into the lake was a human growth hormone. On Craig's boat, Amber, Jagger, Luke, and Craig discover that the snake heads are cannibals, and commonly eat the juvenile fish. They begin to follow some of the fish, only to almost collide with two fishermen on another boat. The snake heads attack the two boats, and eat Craig, and one of the fishermen, while Luke is knocked overboard, and Jagger accidentally kills the other fisherman by shooting his boat's gas tank, blowing it up. Amber, and Jagger then crash the boat on an island in the middle of the lake, and become stranded. They try to call the police, although have no reception. They then find Luke washed up the island alive.
Patrick, and Deputy Reece sneak into Jenkins' lab in order to search for anything suspicious. They find a receipt for 5,000 units of human growth hormone. They arrest Jenkins, and he reveals that he put the hormones into the lake in order to increase the fish population for Colin's bait shop after the poisoning process occurred, not knowing the snake heads were still in the lake. On the island, Amber, Jagger, and Luke find a cabin, as well as a half devoured man inside. Luke goes further, and finds a woman being devoured by a snake head. The snake head attacks Luke, injuring his leg in the process, although Amber kills it with an ax.
Patrick soon finds out that Amber is on the lake, and he, and Lori head out to rescue her, with Lori bringing an electric stick that she plans to use to kill the snake heads. However, the snake heads ram the boat, causing Lori to accidentally render the controls useless with the stick, causing them to crash into a dock on the island. They see a giant, whale-sized snake head before heading onto the island. In the meantime, Colin is digging a hole to bury the hormone packages, only to be killed by the snake heads. Meanwhile, Amber, Jagger, and Luke are attacked by snake heads in the house, although manage to kill several, and their screams helps Patrick, and Lori find them, although Luke is still killed.
Patrick, and Lori arrive outside of the house, and give Amber, and Jagger directions to escape while they reach an electrical shed, planning to electrocute all of the snake heads in the lake. Lori goes to rescue Amber, and Jagger, and the three girls kill all of the remaining snake heads at the cabin before Patrick knocks down an electric cable. When Lori, Amber, and Jagger arrive at the dock, Lori dumps the cable into the water, electrocuting, and killing all of the remaining snake heads. Patrick, Lori, Amber, and Jagger embrace as the fried snake head bodies burn in the water.
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