When Charlie jumps into the lake with Jessie, he is wearing solid navy blue boxer shorts. Later when Charlie tells Louis to get his scissors out of his pocket, Louis lifts up his shirt and grabs the scissors and reveals that his boxer shorts have changed to green with a design, even though they are traveling with no additional clothes.
When Charlie is about to jump into the water fall pool with Jessie he is still wearing the "body paint" they used to disguise their scent from Kangaroo Jack. Before he jumps in, his paint disappears and reappears with each shot. He finally jumps in and without scrubbing at all, and comes out spotless and free of body paint.
When confronted by dingos, the shadows of Charlie and Louis are to the right in the ground level shot, yet the immediately following aerial shot shows the shadows pointing in the exactly opposite direction.
After Louis and Charlie manage to take control of the situation with Smith's men, Charlie takes one of the men's shotguns. He cocks the gun twice, without firing it. The first time is when he first finds the gun, and the second is when Smith is trying to discourage him to not shoot him.
While the kangaroo kicking Charlie is shot in broad daylight, the reaction shot of Charlie falling on his back was clearly shot at near-dusk.
Kangaroos cannot walk backwards.
(at around 1h 11 mins) Frankie is seen shooting a shotgun but there is no kickback of the gun and the way he is holding it (not too steady) there should be a kickback specially in that king of gun.
The propeller was clearly still spinning when the aircraft crash-landed with no undercarriage causing it to touch the ground before the rest of the aircraft. Consequently, its blades should either have been smashed off if it were wood or bent back to point at the tail if they were made of metal. Instead, they are shown virtually untouched as it lies in the desert.
The kangaroo is not the 'national symbol of Australia.' The kangaroo and emu are co-national animals.
When the airplane is about to crash the left wing strikes a chimney and breaks off. In the next shot the wing is back on. However, this could merely be a time lapse of prior to crashing.
When Charlie and Louis are on the Flight to Australia, in the exterior shot, the "PAN AM' on the aircraft is backwards.
If the pilot, shot with a tranquilizer dart, is unable to hold the joystick before the crash and has lost all bodily motor skills, how is he able to raise his right hand, let alone speak, immediately after the crash?
When they are walking across the desert after the air crash, their shadows are precisely to their left. Since Australia is in the Southern Hemisphere, this means that they must be walking generally west, yet, in the previous scene, they have only just asked for directions on how to walk east.
In the car chase at the end, we see a camera in one shot, and a few crew members next to a large rock for a few seconds.
Alice Springs is a modern town, with paved roads and home to approximately 27,000 people.
Charlie and Lewis fly to Sydney in New South Wales and are bound to head to Coober Pedy which is in South Australia. However they arrive in Alice Springs first which is Northern Territory. They should have arrived in Coober Pedy first via the Stuart Highway before getting to Alice Springs, and it would have taken about a 3 day drive. In the film they seem to do this trip in a few hours.
When Charlie and Louis land in Sydney, you see the runway numbers depicting runway "24", which Sydney does not have
When receiving their instructions while still in America, Charlie and Louis are told to drive north from Sydney to Coober Pedy to deliver the package to Mr Smith. Coober Pedy is in fact west of Sydney.
If the American gangsters are looking for the two missing couriers in the middle of the desert, why would they throw the pilot out of their car when they realise that they had been his passengers and he might, therefore, have a good idea of where to find them?
According to the plot, Frankie and his gangsters callously leave the pilot Blue and the aboriginal driver Mr Jimmy to die in the blazing desert. Blue has already complained about how he had been left to die in the desert when Frankie picks him up and, shortly after, he is thrown back out with no further mention in the script.