No, none of the villians from the comics appear at all. However Professor Monster resembles Dr. Doom who was a Fantastic 4 villian and one of the Machine Bems resembles Ben Grimm/The Thing one of the Fantastic 4 members.
Motorcross racer Takuya Yamashiro battles the evil forces of Professor Monster and his Iron Cross Army as the superhero Spider-Man, aided by the transforming mecha Leopardon.