Although Blossom lives with both of her parents in the Pilot,the show was re-tooled for the rest of the series. The parents are divorced, and Blossom lives with her father. However, in the pilot, Blossom's father is named Terry (played by Richard Masur) and works as an accountant. But for the rest of the series, her father is named Nick (played by Ted Wass) and works as a musician.
Having to find the part of Blossom's brother Tony, Mayim Bialik picked the actor to play her brother Tony (Michael Stoyanov) because she thought Michael looked more like her than her real-life brother.
In the series Joey (Joey Lawrence) is a year older than Blossom (Mayim Bialik), but in real life, Mayim is 4 months older than Joey.
Blossom's middle brother was called Donnie in the pilot. However, in the series, he was renamed Joey, but Joey Lawrence always played the role.
"Blossom" (1990) was a clue on the show "Jeopardy! Episode #33.162 in 2017. And now, Mayim Bialik hosts Jeopardy.