When Stump asks for a stock tip he is told to buy Coke stock as it is about to come out in cans and he says Coke in cans I don't believe so. This movie takes place in 1960 and Coke first came out in cans in 1955.
Cobb is seen being treated by a black nurse at Emory University Hospital shortly before his death. In 1961, Georgia hospitals and their staff were still strictly segregated.
In the panoramic shot of of downtown Reno, modern-day casinos are visible that did not exist when Ty Cobb lived in the area.
Near the end of the film and in the bathroom of the Southern Comfort Motel where Ty coughs up blood into the sink, there is a three pronged grounded outlet on the wall. These outlets weren't used until 1962 and even by 1969 only half of American structures had them installed.
When Stumpy and Ty are en route to Cooperstown, NY, they are shown pulling out of a desert gas station with a Route 66 sign on the roadway. Route 66 is very far south of where their route would've taken them.