- James 'Jim' Richardson: Well, at least Snyder will get his name in the Guinness book of records. I mean, causing two nuclear explosions in one afternoon has to be some sort of record.
- James 'Jim' Richardson: [Going over a checklist] Umbilicals?
- Captain Phillip Laidlaw: Clear.
- Snyder: Check.
- James 'Jim' Richardson: Henweigh?
- McBride: Henweigh ready.
- Snyder: Wait, wait, wait, uh, what's a "henweigh?"
- James 'Jim' Richardson: Oh, about three to four pounds.
- Snyder: [the others laugh] Very funny, assholes!
- Dr. John Van Gelder: It'll go supercritical soon.
- Scarpelli: What happens when it goes supercritical?
- Dr. John Van Gelder: It'll explode.
- James 'Jim' Richardson: Welcome to ground zero.
- Osborne: [His last lines] I don't see anything... wait a minute...
- [On seeing the creature]
- Osborne: Holy shit... I DON'T FUCKING BELIEVE IT... LOOK AT THE FUCKING SIZE OF THAT THING OH MY GOD... GOD
- John 'Johnny' Hodges: [His last lines] Shut up and get the hell out of here... GET THE HELL OUT OF HERE