A wolf is ordered by his wife to hunt down dinner, and Bugs Bunny is more than happy to show the forgetful predator all of the best techniques for catching rabbit.
The Coyote chases a speeding cloud that turns out to be Bugs Bunny! He explains that he's standing in for the Road Runner, so Wile E. Coyote tries fishing with carrots and other methods to catch the rabbit.
Bugs refuses to leave his hole so a construction worker can build a highway there. They both play many pranks on each other but in the end they build the highway around Bugs' hole so everyone is happy.
Bugs decides to travel to Chattanooga. He hitches a ride on a train where he meets two bums who are so hungry that at first sight they yell "food"! The bums chase him all across the train.
Yosemite Sam decides to marry Granny for an inheritance she received, but Bugs vows to defend her, as only he can. Meanwhile, Sylvester has difficulty catching both Tweety and a "giant" mouse (actually a baby kangaroo).
Bugs takes on first a fiery opera singer and then a brutish gorilla. Meanwhile, Sylvester consults a psychiatrist on his inability to catch Tweety, while a weasel goes after Foghorn Leghorn.
Bugs outwits a rabbit-hunting robot made by Elmer Fudd, who must also contend with his dog's cynical view of humanity. Elsewhere, Sylvester stalks Tweety on a tugboat, while Pepe Le Pew amorously pursues Penelope up the Matterhorn.
Bugs Bunny contends first with the Big Bad Wolf and then a pair of hillbillies. Meanwhile, Mr. and Mrs. Sylvester become the parents of a baby mouse, and two other mice, Bertie and Hubie, play psychological tricks on Claude Cat.