According to Tommy Chong and various sources, this movie made more money on a second-run on double-bill with The Blues Brothers (1980) than it did on its first release. Interestingly, Paul Reubens appears in both films.
On the wall where the phone is in their house is some graffiti "Dave's not here" a reference to one of their earlier audio sketches
This is the first motion picture to feature Paul Reubens as Pee Wee Herman. When Cheech & Chong are fixing up the van, the song "Tequila" by The Champs is playing. This is the song that Pee Wee Herman would dance to in Pee-wee's Big Adventure (1985).
In the scene where Red steals a Ferrari from the Comedy Store, the license plate on the car is OU812, which Van Halen used for their album of the same name.
Cheech's boss' name - Stromberg - is a reference to the "Up His Nose" skit, from their 1973 album 'Los Cochinos.'