Because this show was produced by the same company that produced Family Affair (1966) and My Three Sons (1960), there were crossover episodes featuring characters from both of those shows.
To Rome With Love was switched to Tuesdays at 9:30 in September, 1970. In order to give Forsythe a strong co-star, Walter Brennan joined the cast as Michael Endicott's father-in-law, Andy Pruitt. However, the second season did even worse than the first. In January, 1971, in an attempt to salvage the series, CBS shifted the show to Wednesdays to make room for a new CBS sitcom: All In The Family. The move did not help, and the series was canceled in the spring of 1971.
In season two, Anissa Jones and Johnnie Whitaker from Family Affair appear on the show on episode 4, "Roman Affair." Episode 6 featured William Demarest, Don Grady, and Tina Cole from My Three Sons in "Rome is Where You Find It."