The interior set at Paramount Studios representing the first floor of Norma Desmond's mansion in Sunset Boulevard (1950), starring Gloria Swanson, was also used in this film, giving fans of that classic a rare opportunity to see it in full color.
John Alexander, who plays Teddy Roosevelt, also plays Teddy Brewster in "Arsenic and Old Lace". Teddy Brewster is under the delusion that he is Teddy Roosevelt.
In a scene involving Lucille Ball and Bob Hope on a mechanical horse, Hope took a tumble off the horse and suffered a mild concussion.
One of the ancestral portraits shown by Humphrey actually represents Lady Godiva, Countess of Mercia, who rode through the streets of Coventry naked, in protest of her husband's excessive taxation of his people. The movie prop is an adaptation of pre-Raphaelite John Collier's 1897 painting, which now hangs in Coventry's Herbert Art Gallery and Museum. However, for Hollywood in 1950, Godiva has acquired a tulle wrap to hide parts of exposed flesh.