In January 2023, Cardwell was diagnosed with stage IV adrenocortical carcinoma. She confirmed her diagnosis in March and said that the cancer was discovered in her lung, liver and kidney. By July, she underwent four rounds of chemotherapy, but the cancer became terminal by that time and she has stopped her treatment. On December 9, 2023, Cardwell died from complications of adrenocortical carcinoma at her mother's home in Georgia at 11:12 pm at the age of 29, on her daughter Kylee's 8th birthday.