- Was one of the three finalists to play Spartacus in the show Spartacus after Andy Whitfield was unable to continue playing the character on the hit show.
- Older cousin of Robbie Amell.
- He has played the same character (Oliver Queen / Green Arrow) in six different television series: Arrow (2012), The Flash (2014), Supergirl (2015), Vixen (2015), DC's Legends of Tomorrow (2016) and Batwoman (2019).
- First child, daughter Mavi Alexandra Jean Amell, was born, October 15, 2013, with his wife Cassandra Jean Amell.
- Is a lifelong professional wrestling fan and has been able to go into the ring against famous WWE wrestlers like Stardust and Triple H.
- He is the second Canadian actor to portray Casey Jones in a live action Ninja Turtles film.
- Is a co-owner of a winery in Washington called Nocking Point.
- Started a Crowdrise campaign for first responders and wildfire victims of Southern California fires (2018).
- Frequently collaborated with the F*ck Cancer Charity Foundation in an effort to raise money for the organization.
- He is of English, Scottish, German, and approximately one sixteenth French-Canadian, descent. His family's surname, "Amell", was spelled "Hamel" several generations back, and originates in France.
- Attended an all boys private school: St. Andrew's College located in Aurora, Ontario.
- Stephen's great-great-great-grandfather, Benjamin Devitt, was Mayor of Waterloo, Ontario, while Stephen's great-great-grandfather, Louis Jacob Breithaupt, was a manufacturer and political figure in Ontario, who was Mayor of Berlin, Ontario (now Kitchener, Ontario), as was his own father before him. Stephen's great-great-uncle, Louis's son Louis Orville Breithaupt, was an MP in the Canadian Parliament, and then a Lieutenant Governor of Ontario from 1952 to 1957.
- Second child, son Bowen Auguste Amell, was born, May 13, 2022, with his wife Cassandra Jean Amell.
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 2001.
- First cousin, twice removed, of Progressive Conservative politician Bill Davis, who was Premier of Ontario, from March 1, 1971 to February 8, 1985. Stephen's paternal great-great-grandparents, John William Hewetson and Eliza Jackson, were also Bill's maternal grandparents.
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