- Is a professional boxer. And former world champion.
- Is of Native American descent (specifically Cherokee, Nipmuc, and Seaconke Wampanoag) and Cape Verdean ancestry.
- Active supporter of the Missing and Murdered Indigenous Women and Girls (MMIWG) movement.
- Is a former world champion in two weight classes, having held the WBC female middleweight title in 2016 and the WBA, WBO, and IBO female light welterweight titles between 2020 and 2022.
- Started boxing at 14.
- Reis' boxing nickname is that of K.O. Mequinonoag, pulled from the name her mother gave her, which is "the medicine woman of our Seaconke Wampanoag tribe," according to Reis.
- Is the youngest of five children.
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