- Is not English, even though he frequently plays characters who have a English accent.
- Oldest brother is African-American; sister is Vietnamese.
- Took the stage name of David Anders because there is already an actor named David Holt. He made the decision to go by his middle name, Anders.
- Has two brothers, Jason (adopted) and Arik and one sister, Maili (adopted).
- To make ends meet while he pursued his dream, he worked in retail sales and taught tennis.
- Played Philip the Apostle in a regional theater production of Jesus Christ Superstar when he was 17.
- Appeared in The Source magazine in December 2001, in an ad for the rapper Canibus, in which David doubles as the Real Slim Shady himself, Eminem.
- Was accepted at the American Academy of Dramatic Arts in Pasadena, California, but decided to head to Los Angeles instead.
- Named 79th sexiest man in 100 Sexiest Men In The World [Sneak magazine, UK, 2005]
- Just before he landed Alias he played the part of a young Knute Rockne in Rockne: The Musical. The play written by Laurence O'Keefe, of Bat Boy fame, fittingly had its world premiere in South Bend, Indiana.
- Son of Dr. Tony and Jeri Holt.
- Named 83rd sexiest man in 100 Sexiest Men In The World [Sneak magazine, UK, 2004]
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