A frequently successful pageant contestant, he originally finished as 2nd runner-up at the August 2017 Mr. United States pageant. In December 2017, he was crowned as winner after the original winner was disqualified.
On April 4, 2022 Emanuel Anzules appeared on The Weakest Link. When asked by host, Jane Lynch, asked Emanuel why he voted to remove Justine (at stay-at-home-mom) from the team he replied, "I like people who go out an work everyday.".