- Co-created Swamp Thing with Len Wein.
- Took a correspondence course from the Famous Artists School.
- Was mostly self-taught but he did watch TV art instructor Jon Gnagy on Saturday mornings.
- Was a big fan of the comic strips of Hal Forster (Prince Valiant) and Alex Raymond (Flash Gordon).
- Dropped out of high school in 1966.
- Worked at the daily newspaper the Baltimore Sun where he drew editorial cartoons and worked in the production department.
- Contributed illustrations and strips to fanzines Squa Tront and Graphic Showcase which published his 8-page comic "Uncle Bill's Barrel" in 1969.
- Wrightson's first published story was the Marv Wolfman written "The Man Who Murdered Himself" in House of Mystery #179 in 1969.
- His comic cover illustrations included a frightening vampire (House of Mystery #211), an ancient killer tree (House of Mystery #217), ghoulish zombies (House of Secrets #100) and a crazed werewolf (House of Mystery #231).
- His artistic influences included Frank Frazetta, Al Williamson, Al Dorne, Graham Ingels, Jack Davis and Howard Pyle.
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