- Diagnosed with emphysema in December 2000. She smoked up to a pack of cigarettes a day between the ages of 13 and 26, with a two year break.
- Is an anti-smoking activist.
- Has a dog named "MicSpic" in honor of her Hispanic and her husband's Irish backgrounds.
- Face is inspiration/model for mannequins in the Costume Institute of the Metropolitan Museum of Art in New York.
- Her father is American and her mother is from El Salvador.
- Appeared in the nude for a PETA poster stating, "I'd rather go naked than wear fur".
- Used to order Kentucky Fried Chicken Original Recipe for her lunch during modeling shoots for Cosmopolitan magazine
- Holds a Master's Degree in Public Health from Columbia University.
- Announced that she has early stage emphysema from her 10-year smoking habit. She quit smoking in 1995. (2000)
- Finished the 2016 Bank of America Chicago Marathon with a time of 03:47:53.
- Has been on the cover of nearly 1,000 magazines since 1987 including Vouge, Allure, Harper's Bazaar, Esquire, and Elle.
- Due to her collaborative shoots with fellow models Linda Evangelista and Naomi Campbell under photographer Steven Meisel's direction, the girl trio became known as the "Trinity," epitomizing fashion of the day.
- She and Edward Burns welcomed their first child, a baby girl named Grace (b. 25 October 2003)
- Went back to school in 1994 and graduated cum laude in 1999, from the Gallatin School of Individualized Study of New York University (NYU), where she earned a Bachelor of Arts degree with a concentration in Comparative Religion and Eastern Philosophy.
- Despite being a huge yoga enthusiast and majoring in eastern philosophy, decided that she was going back to her Catholic roots and go back to eating meat.
- Was co-owner of Fashion Cafe in New York City. (1996)
- Announced engagement to Edward Burns (2001)
- Finished the 120th Boston Marathon in 2015 with a time of 04:09:27.
- Appeared with supermodel friends Linda Evangelista, Naomi Campbell, Tatjana Patitz and Cindy Crawford in George Michael's music video "Freedom 90" as directed by David Fincher and photographed by Jeff Cronenweth.
- Had Roger Wilson's initials tatooed on her ankle, but got it altered to a rose.
- Spokesmodel of Maybelline.
- Was ranked #6 in Channel 5's "World's greatest supermodel".
- Completed to the 2011 New York Marathon.
- Was an initial product tester for the Apple Watch launch in 2015, participating in the press conference and allowing them to film a segment featuring her use of the Apple Watch to train for a marathon.
- Spokesmodel of Calvin Klein.
- Son, Finn, born January 2006.
- Is a member of Mother's Day Every.
- One of the five supermodels. The others are Claudia Schiffer, Cindy Crawford, Naomi Campbell, and Linda Evangelista.
- Wore a silk-and-lace cap sleeved Galliano gown in her June 2003 wedding to Edward Burns.
- Spokesperson for Balenciaga.
- One of Time Magazine's 100 Most Influential People in the World. [April 2014].
- An Ambassador for Product Red.
- In 2005, began working with the international humanitarian organization CARE and has since become their Advocate for Maternal Health.
- In 2015, she signed an open letter which the ONE Campaign had been collecting signatures for; the letter was addressed to Angela Merkel and Nkosazana Dlamini-Zuma, urging them to focus on women as they serve as the head of the G7 in Germany and the AU in South Africa respectively, which will start to set the priorities in development funding before a main UN summit in September 2015 that will establish new development goals for the generation.
- Is a member of White Ribbon Alliance for Safe Motherhood.
- Attended Monte Vista High School in Danville, CA.
- Spokesmodel of STRENESSE.
- Appeared in a Mario Testino photo shoot for Vanity Fair magazine alongside supermodels Claudia Schiffer, Linda Evangelista, Cindy Crawford Stephanie Seymour and Naomi Campbell. The pictorial covered pages 182 through 193. (September 2008)
- In September 2010, she participated in a CARE Learning Tour to Ethiopia to investigate the work being done to reduce maternal deaths.
- Completed to the 2013 New York Marathon.
- On of People Magazine's 50 Most Beautiful People (1993)
- Collects pottery.
- Graduated from NYU with a degree in Comparative Religion and Eastern Philosophy (1999)
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