- Childhood friend of William Hannah, with whom he attended Compton High School in California (1923-27). He was involved in drawing cartoons for school newspapers, but it was Hannah's prompting which led Spence to work in animation.
- Swedish-American animator, noted for his loose, rubbery animation. His output was prolific and he turned out numerous iconic cartoons for Ub Iwerks, MGM (where he helped create Tom & Jerry) and Hannah-Barbera (assisting in the development of characters for "The Flintstones", "The Jetsons", and "Yogi Bear"). He was a recipient in 1986 of the prestigious 1986 Winsor McCay Award for lifetime achievement in animation.
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